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Since 1928 with the discovery of penicillin, antibiotics have been used to treat bacterial infections. Due to large-scale antibiotic use, there has been an increase in antibiotic resistance infections. Therefore, it is important to identify bacterial targets for new antibiotics.

    To check out the cool new instruments in the Chemical Screening Center, check out https://csc.ucsc.edu                

View our presentation at the UCSC Interdisciplinary Research Symposium entitled, Letting nature lead the way: next-generation antimicrobial drug discovery.  

Adaku Okorie, Alejandro Medina, and Zoe Petroff will be joining our lab as undergraduate researchers. Adaku will be working with Kate on virulence gene characterization. Alejandro will be working with Mane to investigate the virulence mechanisms that iscR regulates during

Laya Ashely and Matthew Loven have received Genomics Institute Research Mentoring Internship program research fellowships!  Congratulations Laya and Matthew! More information here. Laya will be mentored by Karen and will be investigating the relationship between type III secretion and the

Micah Braly has received the Koret Undergraduate Research Scholarship for Winter 2022. Congratulations Micah! More information here. 

Annalyse Lalljie has successfully defended her master’s thesis! Congratulations Annalyse! We wish you the best!

Matthew Loven and Sophia Griffing Comer will be joining our lab as undergraduate researchers. Matthew will be working with Adam Lentz to identify and develop new type III secretion system inhibitors. Sophia will be working with Mané Ohanyan to investigate

Dr. David Balderas has successfully defended his dissertation! Congratulations David! We wish you the best!

Laya will be joinging our lab as an undergraduate researcher working with Karen Hug to investigate the relationship between cell envelope stress and type III secretion. Welcome Laya!

Micah Braly will be joining our lab as an undergraduate researcher and will be working with Kate Schubert to help us understand the regulation of virulence plasmid copy number. Welcome Micah!

Our lab is accepting 3 new graduate students! Mané Ohanyan and Karen Hug will be joining us as Ph.D. students and Annalyse Lalljie as a M.S. student. Welcome Mané, Karen, and Annalyse!

This patent covers our labs T3SS inhibitor screening assay wherein we infect a stable HEK293T cell line comprising an NF-kB reporter with Yersinia or Pseudomonas in the presence of the screening compound. More information here.

Azuah Gonzalez has received an award for her outstanding poster presentation at the 2019 Annual Biomedical Research Conference for Minority Students. Great job Azuah!

Natasha Tanner has received an award for her outstanding poster presentation at the fall 2019 meeting of the Northern California American Society for Microbiology. Great job Natasha!

Mariana Prado Martinez will be joining our lab as an undergraduate researcher and will be a part of our iT3SS team working with Hanh Lam to investigate inhibitors of the T3SS. Welcome Mariana!

Hadley Osman will be joining our lab as an undergraduate researcher and will be working with Hanh Lam to help contribute to our understanding of ExoU, an effector protein secreted through the T3SS by Pseudomonas aeruginosa. Welcome Hadley!

Hanh Lam has received a K99 grant from the NIH NIAID! The grant from the National Institute of Allergy and Infectious Diseases will support Hanh’s ongoing research to develop novel therapeutics to combat infections caused by Pseudomonas aeruginosa. Congratulations Hanh!

Dr. Diana Hooker-Romero has successfully defended her dissertation! Congratulations Diana! We wish you the best!

Annalyse Lalljie will be supported for the 2019-20 academic year by our UCSC Giving Day donation fund! A big thank you to everyone who donated!

Adam Lentz has received a Koret Undergraduate Research Scholarship for Winter 2019. Congratulations Adam! More information here.

This patent describes using a small molecule compound called Piericidin and a derivative of it called Mer-A 2062B to inhibit the type III secretion system. More information here.

Pablo Alvarez and Azuah Gonzalez have received Genomics Institute Research Mentoring Internship program research fellowships!  Congratulations Pablo and Azuah!  More information here.   Pablo will be mentored by David and will be investigating the role of the YmoA histone-like protein

Kate Schubert has been selected for the MCD NIH training grant! Congratulations Kate!

Check out pages 14-17 of this magazine to find an article about our T3SS inhibitor screen!

Join us in congratulating David Balderas for receiving a Genomics Institute Research Mentoring Internship graduate fellowship. Congratulations David!

Justin Luu received an award for his outstanding poster presentation at this year’s Annual Biomedical Research Conference for Minority Students. Congratulations Justin!